Overview

• Anvisa published an international notice inviting manufacturers and distributors to propose immediate supply to the public health system, with submissions due within 30 days.
• The Health Ministry asked PAHO for an urgent donation of 100 treatments and signaled plans to purchase 1,000 additional units through the PAHO Strategic Fund.
• Regulators in Argentina, Mexico, the United States, Canada, the European Union, the United Kingdom, Japan, China, Switzerland and Australia were formally consulted on authorization and supply options.
• The procurement specifies fomepizole at 1,000 mg/ml in 1.5 ml ampoules and requires documentation proving capacity for rapid delivery.
• Authorities report 12 confirmed intoxications, 47 under investigation and one death in São Paulo, while labs and 604 compounding pharmacies have been mobilized to test samples and prepare pharmaceutical-grade ethanol as an interim therapy.