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Brain-Computer Interface Enables Real-Time, Expressive Speech for Man with ALS

The trial device decodes neural signals in under 25 milliseconds, recreating pitch, intonation, simple melodies in a synthetic voice

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Overview

  • The interface relies on four microelectrode arrays implanted in the brain’s speech-production region to capture neuronal activity directly.
  • Researchers trained an AI model on thousands of attempted-speech recordings and precondition voice samples to generate a personalized synthetic voice.
  • The participant can modulate emphasis, ask questions, interrupt naturally, and even sing simple melodies through the system.
  • Listeners correctly understood nearly 60% of synthesized words, compared with 4% without the brain-computer interface.
  • Although deployed in the BrainGate2 clinical trial at UC Davis Health, the system has only been tested in one person and requires trials with more participants to validate its effectiveness.