Overview
- In the PVH, AMPK-regulated CRH neurons promoted high-carbohydrate intake, while MC4R-expressing neurons promoted high-fat intake after 2DG.
- NPY neurons in the nucleus of the solitary tract and ventrolateral medulla activated both PVH pathways, enhancing intake of both diet types under glucoprivation.
- NPY neurons in the arcuate nucleus inhibited PVH MC4R neurons, producing an increase in high-fat intake alone.
- The work, led by researchers including Yasuhiko Minokoshi and Ken-ichiro Nakajima at NIPS with collaborators at Nagoya University and Sugiyama Jogakuen University, is published in Metabolism (2025).
- The findings provide first experimental evidence in mice for nutrient-specific control of feeding by distinct PVH circuits using a 2-deoxy-D-glucose model, with implications that remain preclinical.