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Brain Activity Pattern Predicts Imminent Self-Focused Thought

A JNeurosci study links a reproducible resting-state signature to higher internalizing scores after validation in 1,086 Human Connectome Project scans.

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Overview

  • In an experimental sample of 32 adults, a recurring pattern during brief rest forecast self-related thoughts a few seconds later.
  • Population analysis showed that individuals with higher internalizing scores moved in and out of this signature more often during rest.
  • The results are correlational and demonstrate near-term cognitive prediction rather than prospective clinical forecasting.
  • The authors say they are testing whether the signature can predict depression or anxiety onset and whether it relates to real-world social network positions.
  • The peer-reviewed study by Danika Geisler and Meghan Meyer of Columbia University was published in JNeurosci with DOI 10.1523/JNEUROSCI.0037-25.2025.