Overview

• The cohort includes more than 2,000 participants born from 1998 to 2000 across 22 U.S. cities, with an average current age of 23.
• Families reported socioeconomic, neighborhood, environmental, school, behavioral and psychosocial factors up to seven times during early life.
• As young adults, all participants completed health questionnaires and about three-quarters underwent in-person exams, lab testing and carotid ultrasound to assess early arterial injury.
• Investigators published the study’s rationale, design, methods and participant characteristics online August 29, 2025 in the Journal of the American Heart Association, and analyses linking childhood exposures to cardiovascular measures are underway.
• The project responds to American Heart Association projections of rising CVD and hypertension by 2050 and is funded by NHLBI grant R01 HL149869 with additional support from Princeton University and Northwestern University Feinberg School of Medicine, with a disclosed unpaid AHA fiduciary role for Dr. Lloyd-Jones.