Overview

• Patients with AMD exhibit lower circulating ApoM levels than healthy individuals.
• ApoM orchestrates beneficial cholesterol pathways and activates lysosomal acid lipase to clear excess lipids.
• Elevating ApoM in mouse models reduced retinal lipid deposits and restored photoreceptor function.
• Beneficial outcomes depend on ApoM’s binding to sphingosine-1-phosphate to trigger lipid catabolism.
• Researchers have founded Mobius Scientific to advance ApoM-based treatments for AMD and possibly heart failure.