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BMJ Umbrella Review Finds No Causal Link Between Prenatal Paracetamol and Autism

Health agencies continue to recommend paracetamol in pregnancy as the safest analgesic.

Overview

  • Published on November 10, 2025, the BMJ analysis finds available evidence insufficient to show that in‑utero paracetamol exposure causes autism or ADHD.
  • The authors rate many earlier observational studies as low or very low quality because of confounding factors such as maternal health and genetics.
  • This umbrella review compiles prior systematic reviews rather than new primary research, providing the most comprehensive appraisal of the evidence.
  • The findings counter recent claims by President Donald Trump and Health Minister Robert F. Kennedy Jr. urging pregnant women to avoid paracetamol.
  • The WHO and clinical experts reaffirm paracetamol as the preferred painkiller in pregnancy, noting known fetal risks linked to aspirin and ibuprofen.