Overview

• The CORE model uses age, sex and three routine enzymes (AST, ALT, GGT) to calculate a person’s 10‑year risk of severe liver disease, with a free calculator available at www.core-model.com.
• Developed from health‑check data on more than 480,000 Stockholm residents with up to 30 years of follow‑up, the model was externally tested in cohorts from Finland and the UK.
• CORE demonstrated about 88% discrimination for predicting severe outcomes and outperformed the FIB‑4 score, which showed around 79% in the reported comparison.
• Study authors caution that further evaluation in higher‑risk groups such as people with type 2 diabetes or obesity is needed before routine clinical use.
• Investigators highlight potential for earlier detection in primary care and disclose multi‑institutional funding and unrelated industry collaborations.