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2d ago

Blood Test of Brain’s Biological Age Predicts Alzheimer’s Risk and Mortality

Researchers plan to commercialize the organ-age proteomic test within two to three years for personalized preventive health

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New research from Stanford scientists found that an “extremely aged” brain was associated not only with an increased risk of developing Alzheimer’s disease, but a 182% increased risk of dying in the next 15 years.
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Overview

  • Analysis of blood samples from 45,000 UK Biobank participants measured over 3,000 organ-specific proteins to estimate biological age for 11 organ systems.
  • Participants with extremely aged brains faced a twelvefold higher risk of Alzheimer’s diagnosis over a decade and a 182% increase in all-cause mortality over 15 years.
  • Those with extremely youthful brain profiles experienced a 40% reduction in mortality compared with peers of the same chronological age.
  • Stanford teams are advancing the test toward market availability in two to three years, initially targeting key organs such as the brain, heart and immune system.
  • Exercise and non-smoking were linked to younger organ ages, and researchers are now planning trials to assess if lifestyle interventions can slow or reverse organ-specific aging.