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Blood Test Diagnoses Celiac Disease Without Gluten Challenge

The assay measures interleukin-2 release from gluten-specific T cells in a test tube to streamline diagnosis for patients on gluten-free diets.

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Overview

  • The test exposes patient blood samples to gluten peptides in a test tube and identifies reactive immune cells by measuring interleukin-2 production.
  • Clinical trials with 181 participants demonstrated 90% sensitivity and 97% specificity, including on strict gluten-free regimens.
  • By removing the weeks-long gluten challenge and invasive biopsies, the blood test could increase diagnosis rates among the estimated 80% of undiagnosed patients.
  • Levels of interleukin-2 produced in the assay correlate with symptom severity, offering a prognostic tool without dietary provocation.
  • Researchers are now validating the test across diverse populations and expect it to enter clinical practice within two years.