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Blood Test Detects Cancer Signals Up to Three Years Before Diagnosis

The assay detected tumor DNA in archived blood samples, suggesting new possibilities for routine early cancer screening.

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Overview

  • In a recent Johns Hopkins study the multicancer early detection (MCED) lab test identified cancer-associated genetic material up to three years before clinical diagnosis.
  • Researchers applied advanced genetic sequencing to 52 plasma samples originally collected for cardiovascular research and correctly flagged eight participants showing early tumor DNA.
  • Early detection at this interval could enable intervention when tumors are less advanced and more likely to be curable, researchers say.
  • Investigators emphasize the need for larger trials to confirm accuracy, establish clinical follow-up protocols and measure impact on cancer mortality.
  • Results pave the way for potential annual or biennial blood screening programs across multiple cancer types pending further validation.