Blood Pressure Drug Amlodipine Shows Promise as ADHD Treatment

Research suggests the FDA-approved medication may offer a safer and faster alternative for managing ADHD symptoms compared to current treatments.

Amlodipine, a commonly used blood pressure medication, reduced hyperactivity and impulsivity in animal studies, including rats and zebrafish.
The drug was found to cross the blood-brain barrier, influencing brain regions linked to ADHD symptoms, a discovery that challenges prior assumptions about its function.
Human genetic analyses revealed a link between ADHD and the calcium channels targeted by amlodipine, supporting its potential effectiveness in treating the condition.
Data from the UK Biobank showed individuals taking amlodipine reported fewer mood swings and risk-taking behaviors compared to those on other blood pressure medications.
Researchers highlight amlodipine's well-established safety profile and low risk of misuse, making it a promising candidate for repurposing as an ADHD treatment, particularly for patients unresponsive to current options.