Overview

• CitraBoneQMg combines magnesium and glutamine with citric acid to elevate cellular energy and steer stem cells toward bone formation.
• In a rat cranial defect model, bone regrowth rose 56% versus a citric acid-only scaffold and 185% versus a traditional implant after 12 weeks.
• The scaffold concurrently modulated the AMPK and mTORC1 pathways, a mechanism the researchers associate with faster bone regeneration.
• Investigators reported nerve regrowth and reduced inflammation at the implant site, plus inherent photoluminescent and photoacoustic signals for ultrasound tracking.
• The work is published in Science Advances, a U.S. patent application has been filed, and the approach remains preclinical with human testing still required.