Overview

• Kickoff is 7:15 p.m. ET at Mercedes-Benz Stadium on ESPN, the first game of an MNF doubleheader that continues with Bears–Commanders at 8:15 p.m. on ABC.
• Sportsbooks price Buffalo around -3.5 to -4 with a total near 48.5–50 points, and moneylines roughly Bills -200 and Falcons +165.
• Pregame injury reports list Buffalo without Matt Milano and Damar Hamlin, with Dalton Kincaid and Curtis Samuel questionable; Atlanta is without Darnell Mooney and Clark Phillips III, with A.J. Terrell questionable.
• Most expert panels back Buffalo to win and cover, while projection models and handicappers diverge on the scoring outlook between an over and a lower-scoring, run-focused game.
• A key matchup features Bijan Robinson and Tyler Allgeier against a Bills run defense allowing about 145–146 rushing yards per game, with both teams among the league’s leaders in fewest passing yards allowed.