Overview

• Kickoff is Thursday, Sept. 18 at Highmark Stadium in Orchard Park with streaming exclusively on Amazon Prime Video and a listed start around 8:15–8:20 p.m. ET.
• Al Michaels, Kirk Herbstreit and Kaylee Hartung lead the Prime Video broadcast, with SiriusXM carrying team radio feeds on channels 225 and 226.
• Buffalo enters 2-0 after wins over the Ravens and Jets, while Miami sits at 0-2 following losses to the Colts and Patriots.
• Pre-game injury reports list Bills defenders Ed Oliver and Matt Milano out with Taron Johnson, Shaq Thompson and Cam Lewis questionable, while Miami has right tackle Austin Jackson on IR, Darren Waller out and Jaylen Waddle questionable.
• DraftKings lists Buffalo as a 12.5-point favorite with a 49.5 total, CBS Sports projects a comfortable Bills win, and previews note Josh Allen’s 13-2 record against Miami and key matchups featuring James Cook, De'Von Achane and Tyreek Hill.