Overview

• Buffalo enters 3-0 after a 31-21 win over Miami, while New Orleans is 0-3 following a 44-13 defeat in Seattle.
• BetMGM lists the Bills as 16.5-point favorites, their largest spread since 2021.
• Josh Allen’s offense has not committed a turnover this season, part of 574 straight turnover-free snaps, and RB James Cook ranks second in rushing with a touchdown in seven straight regular-season games.
• Key injuries are in flux: Bills DT Ed Oliver and LB Matt Milano are questionable, as are Saints RT Taliese Fuaga and DE Chase Young, with Buffalo RT Spencer Brown’s status also being monitored.
• The game kicks off Sunday, Sept. 28 at 1:00 p.m. ET on CBS, with streaming available on Paramount+ and Fubo.