Overview

• Kickoff is set for 8:20 p.m. ET on NBC from Highmark Stadium, with streaming available on Fubo, DirecTV and Peacock.
• Buffalo enters 4-0 and New England 2-2 in an AFC East matchup featuring Josh Allen and rookie Drake Maye.
• Consensus odds list the Bills at -8.5 with an over/under of 49.5; money line pricing sits around Buffalo -437 and New England +337.
• SportsLine’s Machine Learning Model recommends Hunter Henry Under 40.5 receiving yards, projecting 24.3 yards for the Patriots tight end.
• The model’s top anytime TD targets include Bills RB James Cook—who has scored in all four games and leads the NFL with five rushing TDs—along with Hunter Henry and Dalton Kincaid at +235.