Overview
- The Saints (0-3) visit the Bills (3-0) on Sunday, Sept. 28 at Highmark Stadium in Orchard Park.
- Betting lines list Buffalo as a sizable home favorite around 15.5 to 16.5 points, with several USA TODAY panelists taking New Orleans against the spread.
- Defensive tackle Ed Oliver (ankle) and linebacker Matt Milano (pectoral) headline Buffalo’s Week 4 injury report.
- With Tyler Bass on injured reserve and his Week 5 return unclear, veteran Matt Prater is set to handle kicking duties after a game-winner in his debut and a miss last week.
- Analysts flag Alvin Kamara as the Saints’ central offensive threat, and coach Sean McDermott urged a loud home crowd to disrupt New Orleans’ no‑huddle looks.