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1h ago

Bills Heavy Favorites to Extend Home Streak vs. Winless Saints on Sunday

BetMGM lists Buffalo by 16.5 points, reflecting a matchup of a high-scoring offense against a struggling attack.

Miami Dolphins v Buffalo Bills
9/26/2025
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Buffalo Bills vs New Orleans Saints preview GFX

Overview

  • Kickoff is Sunday, Sept. 28 at 1:00 p.m. ET at Highmark Stadium on CBS, with streaming on Paramount+ and Fubo.
  • Buffalo is 3-0 after a 31-21 win over Miami and seeks its first 4-0 start since 2020.
  • New Orleans is 0-3 following a 44-13 loss to Seattle and is averaging about 15 points per game with continued red-zone issues.
  • Injury statuses are developing: Bills DT Ed Oliver (ankle) and LB Matt Milano (pectoral) are question marks, as are Saints RT Taliese Fuaga (knee/back) and DL Chase Young (calf).
  • Josh Allen has opened with efficient production and no turnovers, while James Cook enters Week 4 with 284 rushing yards and a rushing touchdown in seven straight regular-season games.