Overview

• Thursday Night Football kicks off at 8:15 p.m. ET at Highmark Stadium in Orchard Park, N.Y.
• Sportsbooks list Buffalo roughly -12.5 to -13.5 with a total near 49.5, making the Bills the week’s biggest favorite.
• Buffalo enters 2-0 and has won six straight versus Miami and 13 of the past 14 meetings; Miami is 0-2.
• Model- and expert-driven previews cite an Over lean on the 49.5 total, and ESPN’s FPI gives Buffalo roughly a 76% win chance.
• Injury notes include Josh Allen’s minor nose issue and reports on Matt Milano (pectoral) and Ed Oliver (foot), while media discussion of Mike McDaniel’s job security remains speculative and tied to Miami’s performance.