Overview
- Sportsbooks list Buffalo by about 15–16.5 points, with several analysts warning this profiles as a potential trap despite the mismatch.
- The Bills have started 3-0 without a turnover and are averaging 34 points and 420 yards per game, with Josh Allen reaching his 200th career passing touchdown in Week 3.
- Injury watch: Bills DT Ed Oliver (ankle), LB Matt Milano (pectoral) and RT Spencer Brown (calf) missed Wednesday; the Saints saw LG Trevor Penning practice fully, while DE Chase Young and OL Dillon Radunz did not practice.
- Buffalo has won 13 straight regular-season home games, and coach Sean McDermott urged fans to "defend our dirt" as the crowd noise factor looms.
- Special teams remains unsettled with Tyler Bass eligible to return from injured reserve in Week 5 and veteran Matt Prater continuing to fill in after a game-winner and a recent miss.