Overview

• Las Vegas lists Buffalo at -15.5 with a moneyline around -1450 against New Orleans at +1000.
• Dimers’ simulations project an 89% Bills win probability with a 31–17 final and identify Over 47.5 as the top betting angle.
• Buffalo opened 3-0 with 30-plus points in every game behind Josh Allen and James Cook, while New Orleans is 0-3 with struggles on third down and the league’s lowest pressure rate.
• Kickoff is Sunday at 1 p.m. ET at Highmark Stadium, and only select regions will see the CBS telecast with Andrew Catalon, Charles Davis and Jason McCourty, per 506sports.
• Bills right tackle Spencer Brown is managing a calf issue that could affect the lineup, with Ryan Van Demark the next-man-up option if needed.