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2h ago

Bills Heavily Favored Over Winless Saints in Week 4 Home Game on CBS

Updated lines alongside simulations reflect Buffalo’s strong position after contrasting Week 3 results.

Will Josh Allen and the Buffalo Bills beat the New Orleans Saints on Sunday? NFL Week 4 predictions, picks, odds preview the game on Sept. 28, 2025.
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Overview

  • Kickoff is Sunday, Sept. 28 at 1 p.m. ET at Highmark Stadium in Orchard Park, N.Y., with TV coverage on CBS and streaming on Paramount+.
  • The Saints are 0-3 after a 44-13 loss to the Seahawks, while the Bills stayed unbeaten with a 31-21 win over the Dolphins.
  • BetMGM lists Buffalo as a 16.5-point favorite with a total of 47.5 and a moneyline of -2000, underscoring the market’s lean toward the Bills.
  • Dimers’ 10,000-simulation model gives Buffalo an 85% win probability with a projected score of 27-17 and a recommended play on Under 46.5.
  • Tickets remain available, with prices starting around $298 and lower-level seats beginning near $336 as of the latest listings.