Overview
- Buffalo visits Houston on Thursday, Nov. 20 at 8:15 p.m. ET at NRG Stadium, streaming on Prime Video.
- Opening numbers list Bills -5.5 with a moneyline around Buffalo -250/Texans +205 and a total of 43.5.
- Early analyst picks lean Texans +5.5 and Under 43.5 at bet365, citing Houston’s defensive profile and the short week.
- C.J. Stroud remains in concussion protocol as of Monday, with Davis Mills expected to start, a variable that could shift lines before kickoff.
- The Texans rank top three in key defensive metrics and allow a league-low 16.3 points per game, while Buffalo has been uneven on the road and has yielded 62 points over its last two games.