Overview
- Sportsbooks make Buffalo a slight favorite at Highmark Stadium, with lines hovering from Bills -1.5 to -2.5 and totals around 44 points.
- Buffalo brings the NFL’s top rushing attack led by James Cook’s league-best 1,532 yards, with Josh Allen posing an added rushing threat.
- Saquon Barkley’s 132-yard performance last week boosts Philadelphia’s ground outlook against a Bills defense allowing an NFL-high 4.1 yards after contact per carry.
- The Eagles could see Jalen Carter and Lane Johnson return if cleared, as Buffalo’s front is headlined by pressure leader Greg Rousseau.
- Buffalo is 11-4 on a four-game win streak and Philadelphia is 10-5 with two straight wins, with national prediction panels divided on the result.