Overview

• New Orleans (0-3) visits Buffalo (3-0) on Sunday, Sept. 28 at Highmark Stadium in Orchard Park.
• USA TODAY’s picks panel shows a widespread expectation of a lopsided line, with many selections built around Saints +16.5 or Bills -16.5.
• Bills Wire frames this as a potential trap scenario given Buffalo’s heavy favoritism and the Saints’ ability to lean on Alvin Kamara.
• Buffalo’s injury watch is headlined by defensive tackle Ed Oliver (ankle) and linebacker Matt Milano (pectoral), with their Week 4 availability unclear.
• With Tyler Bass on injured reserve and uncertain for a Week 5 return, veteran Matt Prater continues to handle kicks after a game-winner in his debut and a key miss last week, while Buffalo’s pass rush seeks consistency against a Saints line ranked 23rd by PFF entering Week 3.