Overview
- The defeat leaves Kansas City 5-4, third in the AFC West, and outside the AFC’s seven-team playoff field, with an 0-4 mark in one-score games after going 12-0 in such contests last season.
 - Patrick Mahomes finished 15-of-34 for 250 yards with an interception, marking his first career game under 50% completions as Buffalo pressured him on 52.6% of dropbacks and sacked him three times.
 - Buffalo complemented its pressure with the ground game as James Cook rushed for 114 yards, the most a running back has gained against the Chiefs this season.
 - Mahomes urged urgency and consistency entering the bye, saying there are "no more chances" to take losses and calling the post-bye stretch an "uphill battle."
 - Right tackle Jawaan Taylor sustained a right ankle injury that will be evaluated during the break, with Kansas City next visiting the AFC West-leading Broncos.