Overview

• The landmark case study provides the first direct evidence that beta-HPV can integrate into skin cell genomes and fuel aggressive cutaneous squamous cell carcinoma
• Genetic analysis revealed the patient’s inherited ZAP70-linked T-cell defect prevented her immune system from clearing HPV, enabling recurrent tumors
• A bone marrow stem cell transplant restored her immunity, eradicated all lesions and other HPV-related growths, and maintained remission over three years
• Public health guidance is stressing that HPV spreads via skin-to-skin contact and oral sex and is urging vaccination, condom use and routine skin and cervical screenings
• Researchers are now evaluating whether existing HPV vaccines protect against beta strains and exploring antiviral therapies for at-risk, immunocompromised individuals