Overview
- Kickoff is Sunday at 8:20 p.m. ET at Levi’s Stadium in Santa Clara, with national coverage on NBC and streaming on Peacock.
- Both teams are 11-4 and already in the postseason, and the winner remains alive for the NFC’s No. 1 seed; Chicago can clinch the NFC North with a win or if Green Bay loses Saturday.
- Sportsbooks list San Francisco around -3 with a total near 52.5 points, and SportsLine’s 10,000-simulation model projects the Over at roughly 53 combined points.
- Chicago enters unbeaten against the spread over its last six games with a league-best +21 turnover differential, while San Francisco has won five straight and leads key offensive efficiency metrics during that span.
- The 49ers could be without tight end George Kittle and receiver Ricky Pearsall, and they continue to manage injuries to defensive leaders Fred Warner and Nick Bosa.