Overview
- The new Discovery Research cohort features teams at Mount Sinai, Mass General Brigham, Weill Cornell, and the University of Minnesota using brain stimulation and circuit mapping to study bipolar disorder.
- Each project will receive up to $4.5 million over three years to examine and manipulate human neural circuitry linked to mood-state changes.
- Mount Sinai secured a three-year, $4.5 million grant led by Ignacio Saez to pair deep brain stimulation with longitudinal multimodal recordings and to run a stereotactic EEG study in an epilepsy cohort to relate neural signals to mood transitions.
- Other project leads include Michael Fox at Mass General Brigham, Charles Lynch at Weill Cornell, and Ziad Nahas at the University of Minnesota, spanning symptom-to-circuit mapping, precision neuroimaging with causal tests, and personalized brain stimulation.
- BD² reports its cumulative commitment now exceeds $106 million, with a fourth funding round open for additional proposals as these newly funded studies move into startup and early data collection.