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Bariatric Surgery Outpaces GLP-1 Drugs in Long-Term Weight Loss

High discontinuation rates underline challenges with GLP-1 therapies due to their lower than expected weight loss.

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Wegovy presentation is displayed in New Columbia, Pennsylvania, U.S., November 13, 2023. REUTERS/Hannah Beier/Illustration/File Photo
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Overview

  • Patients undergoing bariatric surgery lost an average of 58 pounds over two years compared to about 12 pounds for those on GLP-1 medications.
  • Up to 70% of GLP-1 patients stop treatment within one year, undermining sustained weight-loss outcomes.
  • Real-world weight loss from GLP-1 drugs falls well below the 15 to 21 percent range observed in clinical trials.
  • Bariatric surgery patients are 18% less likely to develop psychiatric disorders such as anxiety or substance abuse than those on GLP-1 treatments.
  • Approximately 6% of American adults currently use GLP-1 therapies, fueling increased body lift surgeries for excess skin.