Bacteria Behind Respiratory Infections Found to Deactivate Immune System
University of Queensland researchers reveal how Haemophilus influenzae manipulates immune responses, leading to chronic respiratory illnesses.
Overview
- Haemophilus influenzae can induce tolerance and reduce immune response in human respiratory tissues.
- The bacterium is particularly harmful to individuals with conditions like cystic fibrosis, asthma, and COPD.
- Researchers used lab-grown human nasal tissue to study gene expression changes during infection.
- Findings suggest potential for new treatments that enhance the immune system's ability to detect and eliminate the bacterium.
- The study was published in PLOS Pathogens, offering insights into bacterial persistence and immune modulation.