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Bacteria Behind Respiratory Infections Found to Deactivate Immune System

University of Queensland researchers reveal how Haemophilus influenzae manipulates immune responses, leading to chronic respiratory illnesses.

  • Haemophilus influenzae can induce tolerance and reduce immune response in human respiratory tissues.
  • The bacterium is particularly harmful to individuals with conditions like cystic fibrosis, asthma, and COPD.
  • Researchers used lab-grown human nasal tissue to study gene expression changes during infection.
  • Findings suggest potential for new treatments that enhance the immune system's ability to detect and eliminate the bacterium.
  • The study was published in PLOS Pathogens, offering insights into bacterial persistence and immune modulation.
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