Overview

• Patients with atrial fibrillation at the time of M-TEER face more than twice the risk of death or heart failure rehospitalization within two years compared to those without AF.
• Over 52% of AF patients experienced death or rehospitalization for heart failure within two years after the procedure versus 33% of non-AF patients.
• Immediate procedural success rates were equivalent for patients regardless of atrial fibrillation status.
• Patients presenting with AF showed poorer cardiac remodeling and a higher rate of recurrent severe mitral regurgitation (19% versus 8%).
• Study authors recommend aggressive preprocedural rhythm control and call for larger multicenter trials to confirm these findings and guide clinical practice.