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At-Home HPV Self-Collection Expands Access as U.S. Screening Shifts Toward HPV-First

FDA-cleared home sampling, now endorsed by major guidelines, promises easier access to cervical cancer screening.

Overview

  • The American Cancer Society’s December 2025 update recognizes HPV self-collection as an acceptable screening option.
  • FDA authorization allows people over 21 to collect samples at home for high‑risk HPV testing, reducing barriers tied to clinic visits and pelvic exams.
  • Teal Health reports strong uptake of its authorized at‑home test among women ages 40–65, with nearly half of users overdue or never screened.
  • Cervical cancer is often diagnosed in midlife because HPV infections can take 10–20 years to progress, while screening rates drop in the 40s and 50s.
  • WHO frames cervical cancer as eliminable, with one‑dose vaccine evidence and AI‑assisted tools strengthening prevention, though follow‑up after positive tests remains essential.