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AstraZeneca Strikes $1.2 Billion CSPC Pact for Once‑Monthly Obesity and Diabetes Programs

The lead asset SYH2082 is progressing into Phase 1 following the signing.

Overview

  • The collaboration covers eight programmes, with four initially advanced using CSPC’s AI-driven peptide design and LiquidGel once‑monthly injectable platform.
  • AstraZeneca secures exclusive rights outside China to SYH2082, a long‑acting GLP‑1/GIP agonist, and three preclinical weight‑management assets.
  • CSPC will conduct development through Phase 1 before AstraZeneca takes over later-stage development and commercialisation outside China; CSPC retains rights in China, Taiwan, Hong Kong and Macau.
  • Financial terms include a $1.2 billion upfront payment and up to $3.5 billion in development and regulatory milestones, plus additional commercialisation and sales milestones with tiered royalties.
  • The transaction is expected to close in the second quarter of 2026 and expands AstraZeneca’s weight‑management portfolio alongside its separate plan to invest $15 billion in China through 2030.