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AstraZeneca Breaks Ground on $4.5 Billion Virginia Plant, Expands Scope to Cancer and Weight-Management Drugs

The facility will be the company’s largest site worldwide, reflecting a $50 billion push to expand U.S. operations.

Overview

  • The Albemarle County site at Rivanna Futures raises the budget by $500 million and will add manufacturing for ADC cancer medicines plus drug substance for oral GLP-1, baxdrostat, oral PCSK9 and combination therapies.
  • AstraZeneca projects 600 permanent skilled roles in Virginia and about 3,000 construction jobs, totaling roughly 3,600 positions linked to the project.
  • Work starts immediately with operations targeted in four to five years, using AI, automation and data analytics to optimize production.
  • CMS Administrator Dr. Mehmet Oz attended the groundbreaking, underscoring the administration’s push to onshore medicine manufacturing.
  • Reuters reports the investment follows tariff threats and other pressure on drugmakers, while analysts expect limited impact on overall prices and revenues.