Artificial Lymph Node Innovates Cancer Immunotherapy

Johns Hopkins researchers develop a novel method to activate T cells directly in the body, showing promising results in preclinical models.

The artificial lymph node (aLN) uses hyaluronic acid and immune-stimulating molecules to train T cells.
In mouse models, the aLN significantly expanded cancer-fighting T cells and improved survival rates.
The aLN can potentially simplify cancer treatment by reducing complex cell extraction and manipulation steps.
Researchers observed tumor shrinkage and extended survival in mice treated with the aLN and a checkpoint inhibitor.
Further studies are needed to test the aLN's safety and efficacy in humans.