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Arizona Confirms First U.S. Plague Death of 2025

Coconino County health officials are intensifying wildlife surveillance with an investigation into how a resident contracted bubonic plague.

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Muere residente en Arizona por peste neumónica. | Crédito: Centers for Disease Control and Prevention
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Overview

  • An unidentified Coconino County resident was transferred to Flagstaff Medical Center and died the same day from complications of bubonic plague caused by Yersinia pestis.
  • The fatality is the first plague-related death in the United States this year and the first in northern Arizona since 2007.
  • A sharp spike in prairie dog mortality in early July alerted authorities to Yersinia pestis activity in the region.
  • Officials believe the infection likely stemmed from contact with an infected animal or its fleas and stress that person-to-person transmission remains very rare.
  • Plague remains endemic across the U.S. Southwest with the CDC reporting 5 to 15 human cases annually and underscores the need for prompt antibiotic treatment within 24–48 hours of symptom onset.