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Argentina Sees Spike in Voice Loss Linked to ‘Frankenstein’ COVID Variant

Clinicians now use a telltale throat pain with voice loss to identify likely XFG cases during a lull in testing.

Overview

  • WHO-tracked recombinant Omicron subvariant XFC/XFG has grown rapidly worldwide and is reported as accounting for more than half of recent global cases, with the agency maintaining a low public-health-risk assessment.
  • Argentina’s BEN confirmed XFG locally and found it in 3.37% of 89 samples from March–July, rising to over half of sequenced cases in the most recent subperiod reviewed.
  • After three initial confirmations in Córdoba, the Health Ministry has not issued updated genomic surveillance, so clinicians are leaning on clinical presentation to spot probable infections.
  • Specialists describe a consistent profile that includes dysphonia or aphonia with intense sore throat often likened to a knife, brief loss of smell, and gastrointestinal symptoms without severe disease in most cases.
  • With Nomivac data showing over 99% of people received no COVID dose in 2025, CoNaIn and the government moved to align COVID and flu vaccination guidance for simultaneous administration to defined risk groups.