Overview

• The 20-year-old Chinese patient endured multiple daily, spontaneous orgasm-like sensations for years, severely disrupting her life.
• Doctors ruled out epilepsy and structural causes before diagnosing her with persistent genital arousal disorder under criteria defined in 2019.
• Treatment with risperidone and later olanzapine markedly reduced her episodes, but symptoms returned when she stopped medication.
• Her response reinforces a dopamine dysfunction hypothesis, suggesting that dopamine-blocking medications may offer symptom relief.
• Persistent genital arousal disorder affects up to 3% of people but remains underdiagnosed and lacks standardized care pathways.