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Anti-Inflammatory Diet and Exercise Associated with Better Survival in Stage III Colon Cancer

Data presented at the 2025 ASCO Annual Meeting show that EDIP-based measures of dietary inflammation influence survival independently of celecoxib use.

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Overview

  • Patients in the highest EDIP quintile had an 87% higher risk of death compared to those in the lowest quintile.
  • Combining low-inflammatory diets with recommended levels of physical activity resulted in a 63% lower mortality risk versus high-inflammation, low-activity participants.
  • The EDIP score, validated through food frequency questionnaires, quantifies a diet’s inflammatory potential based on 18 food groups.
  • Celecoxib use did not significantly affect the association between dietary patterns and survival outcomes.
  • When standard treatment yields an 80% five-year survival but 25–35% of patients still recur, dietary and exercise interventions offer a potential path to improved outcomes.