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Anterior Temporal Lobe Anchors Social and Emotional Judgments, Anxiety Alters Its Integration

Moving to complete fine-grained connectivity analyses of the ATL, researchers are securing a balanced sample to assess how gender and sleep quality shape network dynamics.

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It has also been observed that this brain region shows greater activation in people with high levels of anxiety, possibly because anxiety is associated with negative affect during the interpretation of social concepts — such as feelings of inferiority when seeing a winner or intense guilt when making mistakes. Credit: Neuroscience News
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Overview

  • Specialized fMRI techniques addressed previous imaging distortions to pinpoint strong upper-ATL involvement in interpreting social hierarchies and reading emotional facial expressions.
  • Preliminary data show individuals with subclinical anxiety exhibit heightened upper-ATL activity and reduced coordination between semantic and emotional processing systems.
  • A July 2025 Sleep Medicine paper reports that individual sleep quality moderates functional connectivity patterns linked to sensitivity to punishment and reward.
  • Researchers are mapping both functional and structural ATL connections, including the uncinate fasciculus linking the ATL to the orbitofrontal cortex, to clarify pathways underlying anxiety and guilt.
  • The team is recruiting a gender-balanced sample to ensure accurate evaluation of demographic influences on ATL network function.