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Ancient DNA Points to Paratyphoid and Relapsing Fever in Napoleon’s 1812 Retreat

Shotgun sequencing of teeth from 13 Vilnius burials revealed infections that complicate the long-held typhus narrative.

Overview

  • An Institut Pasteur–led study in Current Biology analyzed dental pulp from 13 soldiers recovered in a 2001 Vilnius mass grave.
  • Researchers detected Salmonella enterica consistent with paratyphoid in four individuals and Borrelia recurrentis linked to louse-borne relapsing fever in one, possibly two.
  • The metagenomic approach did not find typhus in these samples, contrasting with a 2006 study from the same cemetery that identified DNA from typhus and trench fever.
  • The findings support a multifactorial picture of mortality involving extreme cold, starvation, exhaustion and multiple infectious diseases described in contemporary accounts.
  • The authors caution that the sample size is small and urge broader sequencing across more remains and sites to clarify the full disease spectrum of the 1812 retreat.