Overview

• Schumer, 44, posted an Oct. 4 photo from a Las Vegas outing with Alex Saks and Jillian Bell, drawing praise from friends including Lee Daniels, Margaret Josephs, Chelsea Handler and Amy Sedaris.
• The image shows a noticeably leaner frame as she wears a black Miu Miu mini shirt dress and heels at a Paul McCartney concert.
• She has spoken openly about past use of semaglutide drugs such as Ozempic and Wegovy, saying severe nausea left her bedridden and that she carries a GDF15 gene linked to heightened nausea.
• In March, she said she was seeing positive results with tirzepatide (Mounjaro) alongside estrogen and progesterone via telehealth provider Midi Health, noting better energy, skin and hair.
• Her health updates this year have also included disclosing a 2022 liposuction procedure and sharing August images recovering from an L5 laminectomy.