Overview

• A Oct. 4 Instagram photo from a Las Vegas night out with Alex Saks and Jillian Bell showed Schumer’s noticeably leaner figure in a black Miu Miu mini dress and heels.
• Celebrities flooded the comments with compliments — including Lee Daniels, Margaret Josephs, Amy Sedaris, Chelsea Handler and Isla Fisher — and Schumer replied, “Loving the love. My legs thank you!”
• Schumer has said her current results follow a regimen of tirzepatide (Mounjaro) with estrogen and progesterone via telehealth provider Midi Health, reporting better energy, fuller hair and improved skin.
• She previously described severe nausea and exhaustion on semaglutide (Ozempic/Wegovy), citing a GDF15-related predisposition, and said the rapid weight loss then was not livable.
• The comedian, who disclosed liposuction in 2022 and advocates transparency about medical and cosmetic treatments, is also recovering publicly from an August laminectomy for L5 spine pain.