Overview
- Kickoff is at 5:00 p.m. in Colombia, Ecuador and Peru, with TV coverage in Colombia on Win Play and Win+.
- América must win by three to level the series and force penalties or by four or more to advance directly, after losing the first leg 4–1 in Medellín.
- Atlético Nacional coach Diego Arias cautioned that the matchup is not decided and stressed careful preparation for the game in Cali.
- Referee Jairo Mayorga will officiate at Estadio Pascual Guerrero as the rivals play for a place in the Copa BetPlay final.
- Reported probable lineups feature Alfredo Morelos, Marlos Moreno and Matheus Uribe for Nacional, with América listing Jan Lucumí and Cristian Barrios, while reports note América call-ups returning and several Nacional absences.