Overview

• Incidence reversed a prior decline to rise 3.0% annually from 2014 to 2021, with the steepest growth for advanced-stage diagnoses at roughly 4.6% to 4.8% per year.
• Distant-stage disease is increasing across ages, by about 3% per year in men younger than 55 and 6% per year in men 55 and older.
• Mortality continues to fall but much more slowly, easing to about a 0.6% annual decline over the past decade after larger drops in earlier decades.
• For 2025, the American Cancer Society estimates 313,780 new cases and 35,770 deaths, with five-year survival near 100% for early-stage disease versus about 38% for distant-stage.
• Disparities persist as Black men face 67% higher incidence and double the mortality of White men, American Indian and Alaska Native men have higher mortality despite lower incidence, and the highest state death rates are in the District of Columbia (27.5 per 100,000) and Mississippi (24.8).