Overview

• Peer-reviewed research in Alzheimer’s & Dementia identifies the familial SORL1 variant SORLAN1358S as cutting exosome release by about 30 percent.
• Exosomes produced by mutant cells show up to 50 percent lower neurotrophic activity, providing less support for neighboring cells.
• Proteomic analyses indicate shifts in SORLA interaction partners tied to exosome biogenesis, with altered microRNA cargo in the vesicles.
• The team tested human iPSC-derived neurons and microglia and used omics and functional assays to quantify deficits in intercellular signaling.
• Researchers outline potential therapies that stimulate SORLA or other receptors to boost exosome output, emphasizing that the evidence is preclinical.