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Allen Brain Cell Atlas Expands With 3 Million Parkinson’s Disease Cells

The integration of 3 million patient-derived cells establishes a uniform framework for cellular mapping across neurodegenerative disorders.

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Overview

  • The Atlas’s cell-type database has grown by nearly 50%, now encompassing data from nine brain regions of individuals with Parkinson’s disease.
  • This marks the first inclusion of patient-derived Parkinson’s datasets in the Allen Brain Cell Atlas, which launched in 2023.
  • Scientists can access the expanded resource through the ASAP CRN Cloud platform managed by The Michael J. Fox Foundation.
  • A shared cell-type vocabulary allows direct comparison of cellular changes in Parkinson’s, Alzheimer’s, and related disorders.
  • High-resolution single-cell genomics in the Atlas aims to accelerate identification of vulnerable brain cell types and therapeutic targets.