Overview

• Researchers at Baylor College of Medicine and the Duncan Neurological Research Institute used the Digital Sorting Algorithm to deconvolve mixed-cell data and isolate neural progenitor cell markers.
• The study mapped 129 genes enriched in mouse neural progenitor cells that reside in the hippocampal dentate gyrus, a rare and hard-to-isolate population.
• Cross-referencing human datasets showed 25 orthologs are already known to cause specific neurological diseases when mutated.
• The analysis nominated 15 additional candidate genes bearing rare damaging variants linked to neurological phenotypes that require further validation.
• Findings were published in Stem Cell Reports (DOI: 10.1016/j.stemcr.2025.102606), with the dataset released as a community resource to guide experimental and clinical follow-up.